Control of Kidney Development by Sox4 and Sox11 Transcription Factors

Sox4 和 Sox11 转录因子对肾脏发育的控制

• 批准号: 287005
• 负责人: Hartwig Sunny
• 金额: $ 10.93万
• 依托单位: University of Prince Edward Island (Charlottetown)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-03-01 至 2017-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=287005&lang=en
• 关键词: Glomerular Disease; Kidney Development; Nephrogenesis; Nephron Progenitor Survival And Self-Renewal; Sox11; Sry-Related Hmg Box 4 (Sox4); Transcription Factor Signaling; Wilms' Tumour Suppressor-1 (Wt1)

The childhood kidney diseases Frasier Syndrome and Denys Drash Syndrome are associated with a poorer quality of life, the need for dialysis, and in severe cases, end-stage kidney failure requiring kidney replacement. Both of these diseases are linked to g

儿童肾脏疾病Frasier综合征和Denys Drash综合征与较差的生活质量、需要透析有关，在严重情况下，终末期肾功能衰竭需要肾脏置换。这两种疾病都与g有关。