A Facility for Environmentally-controlled Live-Cell Imaging

荧光显微镜和遗传编码荧光蛋白（如绿色荧光蛋白（GFP））的发现，通过允许研究人员观察活细胞中的分子和亚细胞结构，从而使获得细胞和分子过程的空间和时间信息成为可能，彻底改变了细胞生物学。重要的是，荧光显微镜是研究支持疾病和疾病进展的分子机制的有力工具，反过来，这可能为如何治疗折磨加拿大人的疾病提供线索。总的来说，我们的研究项目旨在了解驱动的分子机制：1)细胞器，即“细胞器官”，是如何制造和运作的；2)细胞膜和蛋白质是如何在细胞内调节和运输的；3)病原体是如何相互作用并篡夺其哺乳动物宿主细胞的；4)超声波的生物医学应用。

Fluorescence microscopy, and the discovery of genetically encoded fluorescent proteins like Green Fluorescent Protein (GFP), revolutionized cell biology by permitting researchers to observe molecules and sub-cellular structures in living cells, thus making it possible to obtain spatial and temporal information of cellular and molecular processes. Importantly, fluorescence microscopy is a powerful tool to study the molecular mechanisms that underpin diseases and disease progression and, in turn, this may provide clues on how to treat diseases that afflict Canadians. Collectively, our research programs aim to understand the molecular mechanisms driving i) how organelles, which are the "organs of the cell", are made and function, ii) how membrane and proteins are regulated and transported within cells, iii) how pathogens interact and usurp their mammalian host cells and iv) the biomedical applications of ultrasound.