Improving the binding specificity and affinity of carbohydrate binding modules using computational protein design.

使用计算蛋白质设计提高碳水化合物结合模块的结合特异性和亲和力。

• 批准号: 459063-2013
• 负责人: Chica, RobertoAntonio
• 金额: $ 1.82万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=542150
• 关键词: Improving; binding; specificity; affinity; carbohydrate

Biomass polysaccharides are the most abundant polymers on earth. Enzymes that hydrolyze polysaccharides, such as cellulases and xylanases, are of increasing industrial importance due to their ability to efficiently degrade cellulose or xylan into smaller carbohydrate subunits that can be used as feedstocks for a large number of applications in industry. Because of this, these enzymes are of high commercial value to Buckman Canada, a leading company in the commercialization of cellulase and xylanase enzymes for various industries, most notably pulp and paper.

生物质多糖是地球上最丰富的聚合物。水解多糖的酶，如纤维素酶和木聚糖酶，由于它们能够有效地将纤维素或木聚糖降解成更小的碳水化合物亚基，可以作为工业上大量应用的原料，因此在工业上具有越来越重要的意义。正因为如此，这些酶对加拿大巴克曼公司来说具有很高的商业价值，巴克曼公司是纤维素酶和木聚糖酶商业化的领先公司，主要用于各种行业，尤其是纸浆和造纸。