Alberta Physical Activity and Breast Cancer Prevention Trial: Ancillary Study Examining the Effect of Exercise on Oxidative Stress, Telomere Length and DNA Methylation

艾伯塔省体力活动和乳腺癌预防试验：检查运动对氧化应激、端粒长度和 DNA 甲基化影响的辅助研究

• 批准号: 280441
• 负责人: Friedenreich Christine M
• 金额: $ 44.33万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-03-01 至 2016-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=280441&lang=en
• 关键词: Antioxidant Enzymes; Breast Cancer Epidemiology; Cancer Biomarkers; Dna Damage Response; Dna Methylation; Oxidative Stress; Physical Activity; Randomized Controlled Trial; Telomerase; Telomere Length

Physical activity reduces the risk of breast cancer by 25-30% when comparing the most to least active women. We conducted the Alberta Physical Activity and Breast Cancer Prevention Trial (ALPHA Trial) in Calgary and Edmonton between 2003-2007 to study how

与最活跃和最不活跃的女性相比，体力活动可将患乳腺癌的风险降低25%-30%。2003-2007年间，我们在卡尔加里和埃德蒙顿进行了艾伯塔省体力活动和乳腺癌预防试验(阿尔法试验)，以研究如何