Virulence factors of fungal pathogens

真菌病原体的毒力因子

• 批准号: 105704-2012
• 负责人: Moore, Margo
• 金额: $ 2.48万
• 依托单位: Simon Fraser University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=545202
• 关键词: Virulence; factors; fungal; pathogens

Fungi are important in biotechnology, agriculture and in medicine. Aspergillus species and members of the group Mucorales are filamentous fungi (moulds) that may cause life-threatening disease in susceptible people. Immunosuppressed individuals are at highest risk. Exposure is via airborne fungal spores followed by growth of the fungus in the lung. In some cases, the fungi may spread to other organs such as the brain. Mortality from these infections ranges from 30-80%.

真菌在生物技术、农业和医学中都很重要。曲霉菌和毛霉目的成员是丝状真菌(霉菌)，可能会在易感人群中引起威胁生命的疾病。免疫抑制的个体风险最高。暴露是通过空气传播的真菌孢子，然后真菌在肺部生长。在某些情况下，真菌可能会扩散到其他器官，如大脑。这些感染的死亡率从30%到80%不等。