Cellular mechanisms of amphibian metamorphosis

两栖动物变态的细胞机制

• 批准号: 217484-2013
• 负责人: Helbing, Caren
• 金额: $ 5.03万
• 依托单位: University of Victoria
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=546619
• 关键词: Cellular; mechanisms; amphibian; metamorphosis

Thyroid hormones regulate growth, development, and metabolism. Although important in all vertebrates including humans, the best example of the diverse effects of these hormones is the normal postembryonic development of the frog where thyroid hormones trigger tadpole metamorphosis into a juvenile frog. Tadpoles undergo remarkable remodeling of the body plan in anticipation of the transition from an aquatic to a terrestrial lifestyle. The same hormone can have very different effects on tadpole tissues (for e.g. the tail disappears and the legs grow) and my research program focuses on understanding how these differences come about. We hypothesize that there are specific genes that contribute to these differences and we will identify them and examine the molecular switches that regulate how they work. Understanding this is important because it gives us fundamental information on how hormones can have very diverse effects and it gives us insight into why some tissues are more sensitive to environmental contaminants and how these contaminants could disturb hormone action.

甲状腺激素调节生长、发育和新陈代谢。尽管这些激素在包括人类在内的所有脊椎动物中都很重要，但这些激素的不同作用的最好例子是青蛙的正常胚后发育，其中甲状腺激素触发蝌蚪变态为幼蛙。蝌蚪经历了显着的重塑身体计划的预期过渡，从水生到陆生的生活方式。同样的激素可以对蝌蚪组织产生非常不同的影响（例如，尾巴消失，腿生长），我的研究计划专注于了解这些差异是如何产生的。我们假设有特定的基因导致了这些差异，我们将识别它们并检查调节它们如何工作的分子开关。了解这一点很重要，因为它为我们提供了关于激素如何产生非常不同的影响的基本信息，并使我们深入了解为什么某些组织对环境污染物更敏感，以及这些污染物如何干扰激素作用。