Design and Implementation of Circulatory Oxygen Therapeutics Derived from Human Hemoglobin by Improved Systematic Chemical Coupling and Cross-Linking

通过改进的系统化学偶联和交联从人血红蛋白衍生的循环氧疗法的设计和实施

• 批准号: 297778
• 负责人: Kluger Ronald H
• 金额: --
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-09-01 至 2016-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=297778&lang=en
• 关键词: Avodiance Of Circulatory Stress; Avoidance Of Endothelial Nitric Oxide Scavenging; Circulating Oxygen Carrier; Coupling Of Hemoglobin And Protective Enzymes; Design For Minimizing Vasoactivity; Improved Specific Protein Modification; Specific Cross-Links

Blood collected for transfusions expires after 42 days of refrigerated storage. The oxygen-carrying component inside the cell is hemoglobin, which retains its potential utility. The proposed research will develop efficient processes to convert the recover

用于输血的血液在冷藏42天后过期。细胞内携带氧气的成分是血红蛋白，它保留了潜在的效用。拟议的研究将开发有效的过程来转化回收