Stress and serotonergic signal transduction in prefrontal cortex

前额皮质的压力和血清素信号转导

• 批准号: 341243-2012
• 负责人: Lambe, Evelyn
• 金额: $ 5.17万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=549289
• 关键词: Stress; serotonergic; signal; transduction; prefrontal

A key goal of my research program is to identify the cellular mechanisms that govern the excitability of the prefrontal cortex, a brain region that plays a key role in emotional regulation. This grant focuses on how the relationship between the serotonin receptors and their downstream effectors is altered by exposure to stress during development, in adulthood, or a combination of both developmental and adult stressors. Since serotonin receptors in prefrontal cortex play important roles in controlling emotional responses to the world around us, understanding how stress affects the balance of serotonergic signal transduction is essential to appreciate the cellular mechanisms through which stress changes how we think and feel and cope with subsequent stress.

我的研究计划的一个关键目标是确定控制前额叶皮质兴奋性的细胞机制，前额叶皮质是大脑中在情绪调节中发挥关键作用的区域。这笔赠款的重点是5-羟色胺受体及其下游效应器之间的关系如何在发育期间、成年期或发育和成人应激源的组合中受到压力的影响而改变。由于前额叶皮质中的5-羟色胺受体在控制对周围世界的情绪反应中起着重要作用，了解压力如何影响5-羟色胺能信号转导的平衡对于理解压力改变我们的思维和感觉以及应对随后的压力的细胞机制是至关重要的。