Understanding and predicting patient-specific osteoporotic fractures

了解和预测患者特异性骨质疏松性骨折

• 批准号: 341880-2011
• 负责人: Luo, Yunhua
• 金额: $ 1.46万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=549519
• 关键词: Understanding; predicting; patient; specific; osteoporotic

Osteoporosis has become a worldwide health priority and October 20th, 2009 was designated "World Osteoporosis Day". In Canada, the prevalence of osteoporosis is 21.3% in women and 5.5% in men over age 50. Over 30,000 osteoporotic hip fractures occur each year in Canada. By the year 2041, the number of hip fractures in Canada is expected to quadruple due to population aging and the annual cost of hip fractures is expected to increase to $2.4 billion. Although bone mineral density (BMD) from patients' femur dual energy X-ray absorptiometry (DXA) is currently the reference standard designated by the World Health Organization (WHO) for the diagnosis of osteoporosis, many osteoporotic fractures occur with measurements above the conventional osteoporotic threshold. Therefore, prediction of osteoporotic fractures based on BMD alone is not optimal; other BMD-independent factors such as patient height and body weight also play roles in osteoporotic fractures.

骨质疏松症已成为全球的健康优先事项，2009年10月20日被指定为“世界骨质疏松日”。在加拿大，女性的骨质疏松症患病率为21.3％，50岁以上的男性为5.5％。每年在加拿大发生30,000多种骨质疏松性髋部骨折。到2041年，由于人口衰老，加拿大的髋部骨折数量预计将四倍，髋部骨折的年成本预计将增加到24亿加元。尽管来自患者的股骨双能X射线吸收法（DXA）的骨矿物质密度（BMD）目前是世界卫生组织（WHO）指定的用于诊断骨质疏松症的参考标准，但许多骨质疏松性裂缝都在常规骨质骨质质阈值之上进行测量。因此，仅基于BMD的骨质疏松骨折的预测不是最佳的。其他独立于BMD的因素（例如患者身高和体重）在骨质疏松性骨折中也起着作用。