Engineering intelligent PLGA nanoparticles for site-specific delivery

药物研究中的一个基本探索是开发可以选择性靶向某些细胞的药物递送方法，同时限制周围健康细胞暴露于药物以避免附带损害。纳米颗粒（NPs）的进步正在迅速发展，并为药物递送提供了令人兴奋的前景。聚合物纳米颗粒，我主要关注的递送系统，是药物递送的通用平台，因为它们具有合适的大小以被细胞吸收，具有可以物理或化学修饰的大表面积，并且与其他药物递送系统相比具有优异的安全性记录。

One fundamental quest in pharmaceutical research is developing methods of drug delivery that can selectively target certain cells, while limiting exposure of surrounding healthy cells to the drug to avoid collateral damage. Advancements in nanoparticles (NPs) are rapidly progressing and offer exciting promise for drug delivery. Polymeric NPs, the delivery system I primarily focus upon, are versatile platforms for drug delivery as they are of appropriate size to be taken up by cells, have a large surface area that can be physically or chemically modified, and an excellent record of safety compared to other drug delivery systems.