Post-translational regulation of SIRT1: the impact of activation and subcellular locale on mitochondrial biogenesis in skeletal muscle

SIRT1 的翻译后调控：激活和亚细胞区域对骨骼肌线粒体生物发生的影响

• 批准号: 402635-2011
• 负责人: Gurd, Brendon
• 金额: $ 2.62万
• 依托单位: Queen's University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=550988
• 关键词: Post; translational; regulation; SIRT1; impact

The ability of skeletal muscle to generate force is determined, in part, by the ability of mitochondria within muscle to generate energy. The content of mitochondria within skeletal muscle is therefore an important determinant of exercise capacity, exercise tolerance, and quality of life.

骨骼肌产生力的能力部分由肌肉内线粒体产生能量的能力决定。 因此，骨骼肌内线粒体的含量是运动能力、运动耐力和生活质量的重要决定因素。