Locus coeruleus functional modulation of the hippocampal complex: Behavior and physiology

海马复合体的蓝斑功能调节：行为和生理学

• 批准号: 418300-2012
• 负责人: Martin, Gerard
• 金额: $ 2.91万
• 依托单位: Memorial University of Newfoundland
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Group
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=551331
• 关键词: Locus; coeruleus; functional; modulation; hippocampal

Using animal research, scientists have been able to reveal how hippocampal neurons produce a representation of space, i.e., spatial maps. Our hypothesis is that spatial maps enable us to separate memories and behave appropriately in different locations. Obviously, we need spatial memories to call up the behaviors required for tasks at home, at work and in many other contexts. Our ability to behave flexibly depends on connecting behaviors with locations. Navigational information helps us to identify places. Also, we may believe a place is different if we see a different shape to the walls, or hear new sounds, or smell new smells. A small group of cells in the brain, the locus coeruleus, is known to signal changes or novelty, sending a novelty signal to the hippocampus and other parts of the brain. These novelty signals may cause hippocampal maps to change, and thus permit new, and even contradictory, behaviors to occur in similar spaces.

通过动物研究，科学家们已经能够揭示海马神经元是如何产生空间表征的，即空间地图。我们的假设是，空间地图使我们能够分离记忆，并在不同的位置做出适当的行为。显然，我们需要空间记忆来唤起在家庭、工作和许多其他环境中完成任务所需的行为。我们灵活行为的能力取决于将行为与地点联系起来。导航信息帮助我们识别地点。此外，如果我们看到不同的墙壁形状，或听到新的声音，或闻到新的气味，我们可能会认为一个地方是不同的。众所周知，大脑中的蓝斑是一小群细胞，它发出变化或新奇的信号，向海马体和大脑的其他部分发送新奇的信号。这些新奇的信号可能会导致海马区地图发生变化，从而允许新的、甚至是相互矛盾的行为在类似的空间发生。