The role of PDZ proteins in the regulation of the signaling and trafficking of the corticotropin releasing factor 1 and serotonin 2A receptors

PDZ 蛋白在促肾上腺皮质激素释放因子 1 和血清素 2A 受体的信号传导和运输调节中的作用

• 批准号: 307749
• 负责人: Hammad Maha M
• 金额: $ 7.65万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-10-01 至 2016-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=307749&lang=en
• 关键词: Anxiety; Bioluminescence Resonance Energy Transfer (Bret); Confocal Microscopy; Corticotropin Releasing Factor Receptors; Depression; Endocytosis; G-Protein Coupled Receptors; Molecular Signaling; Pdz-Binding Proteins; Serotonin Receptors

Stress, anxiety and depression are co-morbid disorders that represent a major health concern in Canada, as 16% of adults will be affected by stress, anxiety and depression in their life-time, with women being twice as susceptible to the disease as men. T

压力、焦虑和抑郁是加拿大主要健康问题的共病，因为 16% 的成年人一生中都会受到压力、焦虑和抑郁的影响，女性患这种疾病的几率是男性的两倍。 时间