Investigating the role of Lin28A in human embryonic neural lineage function

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Studies focusing on the early development of the nervous system typically utilize mouse models. While this work has provided tremendous insight into how the cells in the nervous system are formed, the direct relevance to human neural development is not always clear. In this proposal, we will be using the most immature human cells, embryonic stem cells, to understand the earliest changes during neural development including how different types of neural cells form, how neural cells grow, how they take on stem cell properties and how they move.