Robust Instrumental Variables estimators to boost protein biomarkers discoveries using gene expression data

生物标志物可以被定义为用于衡量和评估疾病状态或对治疗的反应的指标。例如，血浆低密度脂蛋白(LDL)胆固醇水平有助于监测患者的总体心血管健康状况。到目前为止，识别包括癌症、心力衰竭和慢性阻塞性肺疾病在内的各种疾病的分子生物标记物(例如蛋白质)的临床需求尚未得到满足。这些指标可用于开发微创和时效的诊断工具，改善患者的护理，降低加拿大卫生系统的成本。

Biomarkers can be defined as indicators used to measure and evaluate the state of a disease or a response to treatment. For example, plasma levels of low-density lipoprotein (LDL) cholesterol help to monitor patients' general cardiovascular health. To date, there is an unmet clinical need to identify molecular biomarkers (e.g., proteins) of various diseases, including cancer, heart failure, and chronic obstructive pulmonary disease. These indicators can yield to the development of minimally-invasive and time-effective diagnostic tools improving patients' care and decreasing costs in the Canadian health system.