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Model-guided mutational analysis to elucidate the mechanisms of APOBEC enzymes

Model-guided mutational analysis to elucidate the mechanisms of APOBEC enzymes
模型引导的突变分析阐明 APOBEC 酶的机制
批准号:
307708
负责人:
King Justin J
金额:
$7.65万
依托单位国家:
加拿大
项目类别:
Studentship Programs
财政年份:
2013
资助国家:
加拿大
项目状态:
已结题
起止时间:
2013-10-01 至 2016-10-01

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中文摘要
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英文摘要
Research in our lab is centered around understanding processes that mutate our own DNA, or the DNA of viruses after they infect cells. All biological organisms have multiple complex and redundant cellular pathways that vigilantly monitor and maintain the
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Pre-clinical development of small-molecule catalytic pocket inhibitors that block AID/APOBEC-driven mutations in cancer development, aggression and resistance.
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