Microfabricated microporous membranes prolong the functional lifetime of a closed-loop insulin delivery implant in a type I diabetic rat model by passively modulating the host immune response

微加工微孔膜通过被动调节宿主免疫反应，延长 I 型糖尿病大鼠模型中闭环胰岛素输送植入物的功能寿命

• 批准号: 315391
• 负责人: Li Jason
• 金额: $ 0.11万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-09-01 至 2015-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=315391&lang=en
• 关键词: Closed Loop Insulin Delivery; Implant Biocompatability; Implantable Device; Insulin Delivery; Responsive Polymer; Type I Diabetes

Objective: Closed-loop insulin delivery systems offer diabetic patients improved glycemic control, compliance and quality of life, however long-term efficacy has yet to be demonstrated due to poor device biocompatibility. Sustained administration of anti-

目的： 闭环胰岛素给药系统可改善糖尿病患者的血糖控制、依从性和生活质量，但由于器械生物相容性差，长期疗效尚未得到证实。持续给予抗-