The critical role of the class III histone deacetylase SIRT2 in stabilizing N-Myc oncoprotein

III 类组蛋白脱乙酰酶 SIRT2 在稳定 N-Myc 癌蛋白中的关键作用

• 批准号: FT120100323
• 负责人: Dr Tao Liu
• 金额: $ 51.32万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2017-03-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT120100323
• 关键词: critical; role; class; III; histone

Cancer is the commonest cause of death from disease in children. Neuroblastoma is the commonest solid tumor in early childhood. This project will investigate the critical roles of SIRT2 protein in increasing the expression of N-Myc oncoprotein and consequently inducing neuroblastoma, and SIRT2 inhibitors as anticancer agents.

癌症是儿童疾病死亡的最常见原因。神经母细胞瘤是儿童早期最常见的实体瘤。本项目将研究SIRT 2蛋白在增加N-Myc癌蛋白表达从而诱导神经母细胞瘤中的关键作用，以及SIRT 2抑制剂作为抗癌剂。