Characterizing the role and regulation of the mammalian tumour suppressor gene Fat4 on metabolism, mitochondrial complex activity and stability

表征哺乳动物肿瘤抑制基因 Fat4 对代谢、线粒体复合物活性和稳定性的作用和调节

• 批准号: 327875
• 负责人: Yau Norman
• 金额: $ 7.65万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-10-01 至 2017-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=327875&lang=en
• 关键词: Cell Growth And Proliferation; Cell Signalling And Cancer; Drosophila Melanogaster Genetics; Fat Cadherins; Mammalian Cell Culture Models; Metabolism; Mitochondria; Molecular And Cell Biology; Planar Cell Polarity

Proper development of multicellular organisms requires a regulated coordination of conserved pathways involved in tissue patterning, cell growth, and axes development. Misregulation of these pathways leads to a multitude of diseases, including defects in

多细胞生物体的正常发育需要组织模式、细胞生长和轴发育中涉及的保守途径的调节协调。这些通路的失调导致多种疾病，包括免疫缺陷。