Automated assays of gap junction functions and screening of drugs for rescuing conduction in heart tissues

间隙连接功能的自动分析和挽救心脏组织传导的药物筛选

• 批准号: 317395
• 负责人: Sun Yu
• 金额: $ 21.92万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-10-01 至 2017-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=317395&lang=en
• 关键词: Arrhythmia; Automated Instruments; Cardiomyocyte; Conduction Measurement; Diffusion Measurement; Drug Screen; Gap Junction; Ips

Sudden cardiac death (SCD) accounts for up to 50% of lives lost from heart disease. The major causes of SCD are genetic problems (present from birth) and ischemic heart disease resulting from poor lifestyle/obesity, both causing life-threatening irregular

心脏性猝死（SCD）占心脏病死亡人数的50%。SCD的主要原因是遗传问题（从出生开始就存在）和不良生活方式/肥胖导致的缺血性心脏病，两者都导致危及生命的不规则运动。