Circumventing Mechanisms of Cancer Therapy Resistance By Targeting DNA Damage Responses in the Tumor Microenvironment

通过靶向肿瘤微环境中的 DNA 损伤反应来规避癌症治疗耐药机制

• 批准号: 318918
• 负责人: Levesque Christine
• 金额: $ 10.93万
• 依托单位: Fred Hutchinson Cancer Center (Seattle)
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-11-01 至 2017-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=318918&lang=en
• 关键词: Bone Microenvironment; Disseminating Tumor Cells; Dna Damage Response Program; Molecular Response To Genotoxic Therapy; Prostate Cancer; Resistance To Apoptosis; Resistance To Therapy; Therapeutic Targets

The spread of tumor cells to distant sites leading to metastasis is a common and lethal manifestation of many cancers. Therapeutic strategies for treating metastatic disease primarily rely on DNA-damaging agents, such as chemotherapeutics or ionizing radi

肿瘤细胞扩散到远处部位导致转移是许多癌症的常见和致命表现。转移性疾病的治疗策略主要依赖于DNA损伤剂，如化疗药物或电离辐射。