Probing Conformationally Excited States of Aggregation-Prone Proteins Involved in Amyotrophic Lateral Sclerosis: SOD1 and TDP-43

探索肌萎缩侧索硬化症中易聚集蛋白的构象激发态：SOD1 和 TDP-43

• 批准号: 319597
• 负责人: Culik Robert
• 金额: $ 9.83万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-11-01 至 2017-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=319597&lang=en
• 关键词: Amyotrophic Lateral Sclerosis; Conformationally Excited States; Nuclear Magnetic Resonance; Protein Aggregation

Protein aggregation is a major topic in contemporary biophysics research due to the observation that oligomeric assemblies of proteins native to the body are found in patients suffering from any of several neurodegenerative diseases, such as Alzheimer's,

蛋白质聚集是当代生物物理学研究中的一个主要课题，这是由于观察到在患有几种神经退行性疾病中的任何一种的患者中发现了身体天然的蛋白质的寡聚体组装，