Host-Parasite Population Dynamics in Free-Running Arenas

自由运行竞技场中的宿主-寄生虫种群动态

• 批准号: 3585-2012
• 负责人: Scott, Marilyn
• 金额: $ 2.99万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=568313
• 关键词: Host; Parasite; Population; Dynamics; Free

Our LONG-TERM GOAL is to identify factors that affect the dynamic interaction between host and parasite population and their environments as a means of anticipating consequences of interventions and environmental changes. Although most lab studies are done on isolated individual hosts using artificial modes of parasite transmission, we have demonstrated limitations in extrapolating to functional host populations. Thus, our SCIENTIFIC APPROACH is to complement tightly controlled research on individual hosts with experimental population-level research. SHORT-TERM GOALS: We are examining how pregnant and lactating mice signal the stress of nematode infection or protein deficiency to the fetus and neonate, the impact of these signals on fetal and neonatal skeletal and immunological development, on the longer-term fitness of the offspring and on host-parasite population dynamics in free-running arena populations. We are also examining the impact of combined stresses of ectoparasites and waterborne zinc pollution on the dynamics of epidemic outbreaks in guppy populations that have different life history traits. IMPACT: The effects of stresses such as parasitism, malnutrition and pollution extend beyond the individual to populations, communities and future generations. Our research will improve understanding of physiological markers in amniotic fluid, the placenta and breast milk that signal maternal stresses to the neonate, and their consequences on tissue development and short and long-term disease resistance. Our research will also take advantage of sets of life history traits that have evolved under different predation regimes in order to consider how zinc pollution alters guppy's ability to resist infectious agents.

我们的长期目标是确定影响宿主和寄生虫种群及其环境之间动态相互作用的因素，作为预测干预措施和环境变化后果的一种手段。 虽然大多数实验室研究都是使用寄生虫传播的人工模式在孤立的个体宿主上进行的，但我们已经证明了外推到功能宿主群体的局限性。 因此，我们的科学方法是用实验群体水平的研究来补充对个体宿主的严格控制的研究。 短期目标：我们正在研究如何怀孕和哺乳期小鼠信号的压力线虫感染或蛋白质缺乏症的胎儿和新生儿，这些信号对胎儿和新生儿的骨骼和免疫发育的影响，对长期健身的后代和宿主寄生虫种群动态在自由运行的竞技场人口。 我们还研究了具有不同生活史特征的孔雀鱼种群中流行病爆发动态的体外寄生虫和水性锌污染的综合应力的影响。 影响：诸如寄生、营养不良和污染等压力的影响超出了个人的范围，影响到人口、社区和后代。 我们的研究将提高对羊水，胎盘和母乳中生理标志物的理解，这些标志物向新生儿发出母体压力的信号，以及它们对组织发育和短期和长期抗病性的影响。 我们的研究还将利用在不同捕食制度下进化的生活史特征集，以考虑锌污染如何改变孔雀鱼抵抗感染因子的能力。