Abrogation of Cancer Cell Extravasation in Renal Cell Carcinoma PDX lines via Invadopodia Dysregulation Mediated by PAK1 Inhibitors.

通过 PAK1 抑制剂介导的侵入伪足失调消除肾细胞癌 PDX 系中的癌细胞外渗。

• 批准号: 324180
• 负责人: Williams Karla
• 金额: $ 0.07万
• 依托单位: London Health Sciences Centre Res. Inc. (Ont.)
• 依托单位国家: 加拿大
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-01-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=324180&lang=en
• 关键词: Avian Embryo Model; Ics Travel Awards; Intravital Imaging; Invadopodia Formation; Renal Cell Carcinoma

For tumor cells to move through the body they need to be able to alter their physical environment. One way they are able to do this is via specialized structures called invadopodia. Invadopodia are unique to highly aggressive tumor cells and are sites of

肿瘤细胞要在体内移动，就需要能够改变它们的物理环境。它们能够做到这一点的一种方式是通过称为侵入伪足的专门结构。侵袭伪足是高度侵袭性肿瘤细胞所特有的，