The development of B cell and antibody responses

抗体是抗感染免疫的重要介质。为了充分有效，它们必须在暴露于病原体后快速有效地产生。然而，为了逃避抗体的识别，许多病原体已经进化出抑制或延迟抗体产生的机制。该研究计划旨在确定这些病原体损害抗体发育的机制。将使用尖端的免疫学技术和充分表征的感染模型来分析感染期间激活的分子和细胞途径导致抗体应答降低。从这项研究计划中获得的知识将帮助我们更好地了解及时发展抗体反应所涉及的基本免疫学过程，这些免疫学过程对于预防病原体至关重要。

Antibodies are important mediators of immunity against infections. To be fully effective, they must be produced rapidly and efficiently following exposure to a pathogen. However, to escape recognition by antibodies, many pathogens have evolved mechanisms to dampen or delay antibody production. This research program is aimed at defining the mechanisms put in place by such pathogens to impair antibody development. The molecular and cellular pathways activated during infection leading to reduced antibody responses will be analyzed using cutting-edge immunology techniques and well-characterized infection models. Knowledge gained from this research program will help us better understand the fundamental immunological processes involved in the timely development of antibody responses that are crucial for protection against pathogens.