Targeting connexin and pannexin communication in demyelinating diseases

脱髓鞘疾病中的靶向连接蛋白和泛连接蛋白通讯

• 批准号: 328707
• 负责人: Bennett Steffany A
• 金额: $ 7.29万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-03-01 至 2016-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=328707&lang=en
• 关键词: Adult Neural Stem Cells; Adult Oligoendrocyte Precursors; Connexin; Demyelination; Intercellular Communication; Medicinal Chemistry; Multiple Sclerosis; Pharmacology; Phytochemistry; Super Resolution Microscopy

Brain cells depend upon a lipid-rich sheath called myelin for their activity and for their protection. In MS, myelin loss precipitates vision, movement, and cognitive deficits. Toxic (damaging) and trophic (protective) signals transmitted through channel

脑细胞的活动和保护依赖于一种叫做髓磷脂的富含脂质的鞘。在MS中，髓磷脂损失导致视觉、运动和认知缺陷。通过通道传递的毒性（损害）和营养（保护）信号