Using genetically engineered mouse models to define variables producing pancreatic ductal adenocarcinoma heterogeneity

使用基因工程小鼠模型来定义产生胰腺导管腺癌异质性的变量

• 批准号: 323460
• 负责人: Kopp Janel
• 金额: $ 46.96万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-03-01 至 2020-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=323460&lang=en
• 关键词: Biomarkers; Diagnostic Gene Signatures; Mouse Genetic Models; Pancreatic Cancer; Pancreatic Ductal Adenocarcinoma; Premalignant Lesions; Tumor Heterogeneity; Tumorigenesis

Tumor heterogeneity is largely thought to arise from different gene mutation events. Mounting evidence also suggests that distinct tumor-initiating cell types, or cells of origin, may also contribute to heterogeneity in prostate and breast cancer. However

肿瘤异质性主要被认为是由不同的基因突变事件引起的。越来越多的证据还表明，不同的肿瘤起始细胞类型或起源细胞也可能导致前列腺癌和乳腺癌的异质性。然而