Chemically-assisted discovery and investigation of antifungal drug leads

抗真菌药物先导化合物的化学辅助发现和研究

• 批准号: 320685
• 负责人: Nodwell Justin R
• 金额: $ 64.65万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-03-01 至 2020-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=320685&lang=en
• 关键词: Antifungal Drugs; Chemical Elicitors; Gene Expression; Signal Transduction; Streptomyces

Fungal infections are very difficult to treat. There are relatively few good antifungal drugs and many fungal pathogens possess resistance mechanisms that render these few drugs relatively useless. One source of new drugs is the 'secondary metabolism' of

真菌感染很难治疗，好的抗真菌药物相对较少，许多真菌病原体具有耐药性机制，使这些药物相对无用。新药的一个来源是药物的“次级代谢”。