The role of genetics and epigenetics in meiotic errors underlying impaired spermatogenesis in male infertility

遗传学和表观遗传学在男性不育精子发生受损的减数分裂错误中的作用

• 批准号: 323703
• 负责人: Ma Sai
• 金额: $ 41.64万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-03-01 至 2020-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=323703&lang=en
• 关键词: Azoospermia; Copy Number Variances (Cnv); Dna Methylation; Male Infertility; Male Meiotic Recombination; Oligozoospermia; Recombination Hotspot; Single Nucleotide Polymorphisms (Snp); Sperm Aneuploidy; Spermatogenesis

Male-factor infertility affects up to 40% of couples struggling with fertility treatments in Canada. What causes this condition, however, remains unknown in many cases. The most common observation is impaired sperm production. Infertile men struggle to pr

在加拿大，男性因素导致的不孕症影响了多达40%正在接受生育治疗的夫妇。然而，在许多情况下，导致这种情况的原因仍然未知。最常见的观察结果是精子产生受损。不育男性很难生育