Tip60/TRRAP- and MRN/ATM-relayed chromatin stress can mediate senescence-associated inflammatory secretion independently of DNA damage

Tip60/TRRAP 和 MRN/ATM 中继的染色质应激可以介导衰老相关的炎症分泌，与 DNA 损伤无关

• 批准号: 331897
• 负责人: Malaquin Nicolas
• 金额: $ 0.07万
• 依托单位: Centre hospitalier de l'Universit de Montral (CHUM)
• 依托单位国家: 加拿大
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-05-01 至 2016-05-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=331897&lang=en
• 关键词: Cancer; Dommage À L'Adn; Phenotype Secretoire Asscocié À La Sénescence; Stress De La Chromatine; Sénescence Cellulaire

In recent years it became clear that cancer treatment do not necessarily trigger simple cancer cell death. For example, if prostate cancer cells simply "died" following treatment, tumors should shrink and disappear in a few days, which is not the case.

近年来，人们越来越清楚地认识到，癌症治疗不一定会引发简单的癌细胞死亡。 例如，如果前列腺癌细胞在治疗后简单地“死亡”，肿瘤应该在几天内缩小并消失，但事实并非如此。