The role of P2X7 and P2X4 receptor mediated innate phagocytosis in pathogenesis and treatment of neurodegenerative diseases

P2X7和P2X4受体介导的先天吞噬作用在神经退行性疾病发病机制和治疗中的作用

• 批准号: FT120100581
• 负责人: Dr Baijun (Ben) Gu
• 金额: $ 52.37万
• 依托单位: The Florey Institute of Neuroscience and Mental Health
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-02 至 2016-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT120100581
• 关键词: role; P2X7; P2X4; receptor; mediated

This project will identify how inherited variation in two proteins of the brain can accelerate the removal of neurones and predispose to a range of neurodegenerative diseases. Knowledge of the biological basis of this finding will allow a search for new compounds which will slow and protect against this form of neurodegeneration.

该项目将确定大脑中两种蛋白质的遗传变异如何加速神经元的去除并使一系列神经退行性疾病易感。对这一发现的生物学基础的了解将允许寻找新的化合物，这些化合物将减缓和防止这种形式的神经变性。