Ketamine-induced NMDA receptor hypofunction in nonhuman primates as a model for cognitive deficits in schizophrenia

氯胺酮诱导的非人灵长类 NMDA 受体功能减退作为精神分裂症认知缺陷的模型

• 批准号: 339376
• 负责人: Ma Liya
• 金额: $ 9.83万
• 依托单位: University of Western Ontario
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-11-01 至 2018-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=339376&lang=en
• 关键词: Animal Model; Computational Property; Electrophysiology; Pharmacology; Prefrontal Cortex; Schizophrenia; Working Memory

Most patients suffering from schizophrenia have cognitive problems. One especially debilitating problem, the working memory deficit, is the impairment in their ability to hold information temporarily on-line for planning, making decisions and interacting

大多数精神分裂症患者都有认知问题。一个特别令人衰弱的问题是工作记忆缺陷，那就是他们暂时在线保存信息以进行计划、决策和互动的能力受损