Mechanisms of Sex Differences in Focal Cerebral Ischemia

局灶性脑缺血的性别差异机制

• 批准号: 339892
• 负责人: Stefanovic Bojana
• 金额: $ 10.82万
• 依托单位: Sunnybrook Research Institute (Toronto, Ontario)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-11-01 至 2017-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=339892&lang=en
• 关键词: Animal Models Of Focal Ischemia; Beta-Hydroxybutyrate; Immunofluorescence; Intracranial Array Electrophysiology; Magnetic Resonance Iamging; Neurovascular Unit; Stroke; Stroke Recovery; Subacute Stage Treatment For Ischemia

Neurons and brain blood vessels work in concert so that blood flow increases when neurons become active. This neurovascular coupling is compromised in stroke, whereby a blockage of a major artery results in a sharp decline in blood flow, causing damage to

神经元和脑血管协同工作，这样当神经元变得活跃时，血流量就会增加。这种神经血管偶联在中风时会受到损害，因此主要动脉的阻塞会导致血流量急剧下降，从而造成脑血管损伤。