Error-prone repair pathways in Huntington's trinucleotide repeat expansion: An investigation into the protein factors contributing to slipped-DNA repair in repeat tracts and their contribution to the tissue specifity of repeat expansion.

亨廷顿氏三核苷酸重复扩增中的易错修复途径：对重复序列中导致 DNA 滑动修复的蛋白质因素及其对重复扩增的组织特异性的贡献的研究。

• 批准号: 350120
• 负责人: Griffiths Nigel
• 金额: $ 1.27万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-12-01 至 2016-12-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=350120&lang=en
• 关键词: Affinity Chromatography; Dna/Protein Assays; Error-Prone Dna Repair; Huntington'S Disease; Molecular Genetics; Pcr; Slipped-Dna Repair; Tissue Specific Repeat Expansion; Trinucleotide Repeats; Western Blotting

The underlying cause of Huntington's disease is the presence of an expanded tract of three-base repeats within the protein coding sequence of the htt gene. Although the length of the repeat tract is a heritable trait, expansion of the repeats can occur th

亨廷顿氏病的根本原因是htt基因的蛋白质编码序列内存在扩展的三碱基重复序列。虽然重复序列的长度是一个可遗传的特征，但重复序列的扩展可以发生在