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Error-prone repair pathways in Huntington's trinucleotide repeat expansion: An investigation into the protein factors contributing to slipped-DNA repair in repeat tracts and their contribution to the tissue specifity of repeat expansion.

Error-prone repair pathways in Huntington's trinucleotide repeat expansion: An investigation into the protein factors contributing to slipped-DNA repair in repeat tracts and their contribution to the tissue specifity of repeat expansion.
亨廷顿氏三核苷酸重复扩增中的易错修复途径：对重复序列中导致 DNA 滑动修复的蛋白质因素及其对重复扩增的组织特异性的贡献的研究。
批准号：
350120
负责人：
Griffiths Nigel
金额：
$1.27万
依托单位：
University of Toronto
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2015
资助国家：
加拿大
项目状态：
已结题
起止时间：
2015-12-01 至 2016-12-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=350120&lang=en
关键词：
Affinity Chromatography Dna/Protein Assays Error-Prone Dna Repair Huntington'S Disease Molecular Genetics Pcr Slipped-Dna Repair Tissue Specific Repeat Expansion Trinucleotide Repeats Western Blotting

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英文摘要
The underlying cause of Huntington's disease is the presence of an expanded tract of three-base repeats within the protein coding sequence of the htt gene. Although the length of the repeat tract is a heritable trait, expansion of the repeats can occur th
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