Novel functions of importin-alpha in RNA metabolism and the stress response

importin-alpha 在 RNA 代谢和应激反应中的新功能

• 批准号: RGPIN-2015-04137
• 负责人: Stochaj, Ursula
• 金额: $ 2.77万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=589614
• 关键词: Novel; functions; importin; alpha; RNA

In eukaryotic cells, the importin-a protein family (here referred to as importin-a) contributes to multiple aspects of cell physiology. Aside from nuclear transport, family members are implicated in additional vital biological processes. Recent studies suggest that importin-a has new functions in RNA metabolism and the stress response. Thus, we demonstrated that importin-a1 binds poly(A)-RNA. We also showed that multiple members of the importin-a family associate with cytoplasmic stress granules (SGs). How importin-a proteins contribute to these crucial cellular activities is not well understood. Our research program will address these central biological questions.

在真核细胞中，importin-a蛋白家族（这里称为importin-a）对细胞生理学的多个方面都有贡献。除了核运输，家庭成员还参与其他重要的生物过程。近年来的研究表明，进口蛋白a在RNA代谢和应激反应中具有新的功能。因此，我们证明了importin-a1与poly(A)-RNA结合。我们还发现，进口蛋白a家族的多个成员与细胞质应激颗粒（SGs）有关。进口蛋白a是如何参与这些关键的细胞活动的还不清楚。我们的研究计划将解决这些核心的生物学问题。