Structure and function of bacterial glycosyltransferase enzymes

细菌糖基转移酶的结构和功能

• 批准号: RGPIN-2015-04622
• 负责人: Whitfield, Christopher
• 金额: $ 4.59万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=589912
• 关键词: Structure; function; bacterial; glycosyltransferase; enzymes

Cell-surface glycoconjugates participate in crucial cellular recognition processes in all biological systems. Glycosyltransferase (GT) enzymes determine the precise order of sugars and linkages in a glycan structure and represent a crucial enzymatic foundation in glycobiology. GTs also have potential biotechnological applications in emerging glycoengineering technologies, where the goal is to produce “glyco-products” with defined chemical and physical characteristics. Bacterial GTs that use sugar nucleotide donors are important in these efforts due to their vast range of specificities

在所有生物系统中，细胞表面的糖偶联物参与关键的细胞识别过程。糖基转移酶(GT)酶决定了糖链结构中糖和键的精确顺序，是糖生物学中一个重要的酶基础。GTS在新兴的糖工程技术中也有潜在的生物技术应用，其目标是生产具有明确的化学和物理特性的“糖类产品”。使用糖核苷酸供体的细菌GT在这些努力中非常重要，因为它们具有广泛的特异性