Role of FXR proteins in the cell stress response

FXR 蛋白在细胞应激反应中的作用

• 批准号: RGPIN-2015-05568
• 负责人: Mazroui, Rachid
• 金额: $ 2.77万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=590510
• 关键词: Role; FXR; proteins; cell; stress

The coordinated control of mRNA translation is fundamental for eukaryotic cell homeostasis, particularly in response to physiological and pathological stress. Alterations of this program can lead to the growth of damaged cells, a hallmark of cell transformation and cancer, or to premature cell death, such as observed in neurodegeneration and infertility. Fragile X-related proteins (FXRPs) are RNA-binding proteins that play a key role in mRNA translation and have a function that is associated with cell stress responses. However, the underlying mechanisms by which FXRPs regulate the mRNA translation that is required for a cell to cope with stress remains largely unknown.

mRNA翻译的协调控制是真核细胞稳态的基础，特别是在响应生理和病理应激时。这一程序的改变可能导致受损细胞的生长，这是细胞转化和癌症的标志，或导致细胞过早死亡，如在神经变性和不育症中观察到的。脆性X相关蛋白（FXRPs）是RNA结合蛋白，在mRNA翻译中起关键作用，并具有与细胞应激反应相关的功能。然而，FXRPs调节细胞科普压力所需的mRNA翻译的潜在机制在很大程度上仍然未知。