Biphasic contribution of prostaglandin E2 to the hypothalamic-pituitary-adrenal axis

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The neural mechanisms that regulate homeostasis must effectively sense perturbations and respond rapidly. This NSERC research program will provide new information about how the brain senses ascending warning signals (e.g. peripheral inflammation), and then activates the hypothalamic-pituitary-adrenal (HPA) axis, an evolutionarily conserved regulator of homeostasis. Our focus is on a key mediator of this inflammation-induced response, prostaglandin (PG)E2, which is produced through the cyclooxygenase (COX) pathway. The established view is that circulating cytokines (i.e. ascending inflammation signals) cause