A significant role for Nef's N-terminal alpha-helix domain in its ability to sequester Lck and inhibit T cell signalling
A significant role for Nef's N-terminal alpha-helix domain in its ability to sequester Lck and inhibit T cell signalling
Nef 的 N 末端 α 螺旋结构域在隔离 Lck 和抑制 T 细胞信号传导方面发挥着重要作用
批准号：
347146
负责人：
Markle Tristan
金额：
$0.11万
依托单位国家：
加拿大
项目类别：
财政年份：
2016
资助国家：
加拿大
项目状态：
已结题
起止时间：
2016-01-01 至 2017-01-01
中文摘要
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英文摘要
The HIV-1 virus expresses a protein, Nef, which can bind to host T cells proteins and alter the cell's activation state. By acting as an "activation switch," the Nef protein may be able to enhance viral replication or, alternately, promote latency. This p
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The N-terminal domain of HIV-1 Nef regulates its ability to inhibit or stimulate T cell receptor-mediated signaling events
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批准号：288445
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项目类别：
-
资助金额：$0.18万
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财政年份：2013
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负责人：Markle Tristan
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依托单位：