A significant role for Nef's N-terminal alpha-helix domain in its ability to sequester Lck and inhibit T cell signalling

Nef 的 N 末端 α 螺旋结构域在隔离 Lck 和抑制 T 细胞信号传导方面发挥着重要作用

• 批准号: 347146
• 负责人: Markle Tristan
• 金额: $ 0.11万
• 依托单位: Simon Fraser University (Burnaby, B.C.)
• 依托单位国家: 加拿大
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-01-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=347146&lang=en
• 关键词: Hiv Latency; Niv-1 Nef; T Cell Activation

The HIV-1 virus expresses a protein, Nef, which can bind to host T cells proteins and alter the cell's activation state. By acting as an "activation switch," the Nef protein may be able to enhance viral replication or, alternately, promote latency. This p

HIV-1病毒表达一种名为Nef的蛋白质，它可以与宿主T细胞蛋白质结合并改变细胞的活化状态。通过充当“激活开关”，Nef蛋白可能能够增强病毒复制，或者促进潜伏期。该p