Biodegradation of Polyfluoroalkyl Chemicals in the Environment

环境中多氟烷基化学品的生物降解

• 批准号: 418649-2012
• 负责人: Liu, Jinxia
• 金额: $ 1.75万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=596459
• 关键词: Biodegradation; Polyfluoroalkyl; Chemicals; Environment

Perfluoroalkyl and polyfluoroalkyl compounds (PFCs) are widely used in surface treatments for industrial and consumer products and as specialty chemicals. Currently, as many as hundreds of different applications have been developed. Though several categories of PFCs are under strict scrutiny for adverse environmental and ecological impact, the high versatility warrants their continuous use into the foreseeable future. Despite overall high stability, some polyfluoroalkyl compounds are susceptible to environmental biodegradation due to the integral aliphatic functionalities. For example, we have discovered that fluorotelomer alcohols can undergo substantial aerobic biodegradation and defluorination, contrary to conventional wisdom. Novel biodegradation mechanisms were discovered to be involved in generating new degradation products previously unknown. These findings have inspired us to re-think the environmental reactivity of highly fluorinated compounds as well as the metabolic capacities of microorganisms in the environment. In this context, we propose to examine three organosulfur polyfluoroalkyl compounds (two perfluoroalkyl sulfonamidoethanols and one fluorotelomer sulfonate) that are prominent environmental contaminants. The major approach is to apply advanced analytical techniques to elucidate aerobic biodegradation pathways and mechanisms of compounds of interest through a series of laboratory experiments. The proposed research will address the fundamental question of by what mechanisms microorganisms can cleave strong carbon-fluorine bonds. By examining the influence of chemical structure on biodegradability and defluorination potential, the research will be providing insights for designing better polyfluoroalkyl chemicals that do not lead to harmful compounds in the environment. The proposed research also has significant applicability to current international concerns by addressing how these compounds are degraded in natural and engineered treatment systems to release potentially toxic pollutants. With better understanding of such fundamental knowledge on environmental sources and fate, future environmental risk assessment and chemical regulations may be more effective in minimizing negative impact of PFCs.

全氟烷基和多氟烷基化合物(PFC)广泛用于工业和消费品的表面处理以及作为特种化学品。目前，已经开发了多达数百种不同的应用程序。尽管几类全氟化碳因其对环境和生态的不利影响而受到严格审查，但其高度的多功能性保证了它们在可预见的未来继续使用。尽管总体上稳定性很高，但由于具有完整的脂肪族官能团，一些多氟烷基化合物容易受到环境生物降解的影响。例如，我们发现含氟调聚物醇可以进行大量的好氧生物降解和脱氟，这与传统的看法相反。新的生物降解机制被发现涉及到产生以前未知的新的降解产物。这些发现启发我们重新思考高氟化合物的环境反应性以及环境中微生物的新陈代谢能力。在这方面，我们建议研究三种显著的环境污染物--三种有机硫多氟烷基化合物(两种全氟烷基磺胺乙醇和一种氟调聚磺酸盐)。主要的方法是应用先进的分析技术，通过一系列的实验室实验来阐明感兴趣的化合物的好氧生物降解途径和机理。这项拟议的研究将解决微生物通过什么机制裂解强烈的碳氟键这一根本问题。通过研究化学结构对生物降解性和脱氟潜力的影响，这项研究将为设计更好的不会在环境中产生有害化合物的多氟烷基化学品提供见解。拟议的研究还通过解决这些化合物如何在自然和工程处理系统中降解以释放潜在有毒污染物，对当前国际关注的问题具有重大适用性。随着对这些关于环境来源和命运的基本知识有了更好的了解，未来的环境风险评估和化学法规可能会更有效地将全氟化碳的负面影响降至最低。