Dynamic modulation of membrane tension and mechanosensitive ion channel activity steers the nerve growth cone

膜张力和机械敏感离子通道活性的动态调节引导神经生长锥

• 批准号: 436091-2013
• 负责人: SharifNaeini, Reza
• 金额: $ 2.33万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=596848
• 关键词: Dynamic; modulation; membrane; tension; mechanosensitive

The precise wiring of the developing nervous system depends on the path-finding abilities of the neuronal growth cone (GC), a highly dynamic sensory structure at the tip of growing axons. Growth cone turning is a fundamental behavior during axon guidance, yet its underlying mechanisms are incompletely understood. The GC membrane contains mechanosensitive ion channels (MSC) that are proposed to sense changes in membrane tension and transduce these changes into electrical signals. The objective of this program is to understand how the GC cytoskeleton, membrane tension, and the activity of mechanosensitive ion channels interact together to steer the growth cone.

发育中的神经系统的精确布线取决于神经元生长锥（GC）的寻路能力，神经元生长锥是生长轴突尖端的高度动态感觉结构。生长锥转向是轴突导向过程中的一个基本行为，但其内在机制尚未完全了解。GC膜含有机械敏感离子通道（MSC），其被提出用于感测膜张力的变化并将这些变化转化为电信号。这个项目的目的是了解GC细胞骨架，膜张力和机械敏感离子通道的活性如何相互作用以控制生长锥。