DNA Replication fork processing and recovery in living Escherichia coli cells

活大肠杆菌细胞中的 DNA 复制叉处理和恢复

• 批准号: DP110102476
• 负责人: A/Prof Ian Grainge
• 金额: $ 20.06万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-05-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP110102476
• 关键词: DNA; Replication; fork; processing; recovery

DNA is the genetic blueprint for all life. When cells divide their DNA has to be copied completely, and exactly, to avoid mutations or death. When the process of copying breaks down, the DNA needs to be repaired and the process of copying restarted. This project will investigate living cells, to understand the mechanisms and pathways involved.

DNA是所有生命的基因蓝图。当细胞分裂时，它们的DNA必须完全复制，以避免突变或死亡。当复制过程中断时，DNA需要修复，复制过程重新开始。该项目将研究活细胞，以了解所涉及的机制和途径。