Genetic mouse models of SHH medulloblastoma for molecular analysis and therapeutics

用于分子分析和治疗的 SHH 髓母细胞瘤遗传小鼠模型

• 批准号: 344030
• 负责人: Hui Chi-Chung
• 金额: $ 62.1万
• 依托单位: Hospital for Sick Children (Toronto)
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-03-01 至 2021-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=344030&lang=en
• 关键词: Btrc; Cchc-Type Zinc Finger; Gli2; Medulloblastoma; Nucleic Acid Binding Protein; Proteasome Degradation; Sonic Hedgehog Signaling; Spop; Spopl; Suppressor Of Fused

Medulloblastoma is the most common malignant childhood brain tumor and is a leading cause of morbidity and mortality in pediatric cancer patients. Among them, infant MB represents the most deadly and difficult to treat subtype of childhood brain tumors be

髓母细胞瘤是儿童最常见的恶性脑肿瘤，是儿童癌症患者发病率和死亡率的主要原因。其中，婴儿MB是儿童脑肿瘤中最致命和最难治疗的亚型