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Inhibition of the enzyme 5alpha-reductase by dutasteride induces neuroprotection of dopaminergic neurons of male mice when administered before but not after MPTP

Inhibition of the enzyme 5alpha-reductase by dutasteride induces neuroprotection of dopaminergic neurons of male mice when administered before but not after MPTP
在 MPTP 之前而非之后给药时,度他雄胺对 5α-还原酶的抑制可诱导雄性小鼠多巴胺能神经元的神经保护
批准号:
352326
负责人:
Litim Nadhir A
金额:
$0.07万
依托单位:
依托单位国家:
加拿大
项目类别:
财政年份:
2016
资助国家:
加拿大
项目状态:
已结题
起止时间:
2016-07-01 至 2017-07-01
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英文摘要
Parkinson's disease (PD) is a progressive brain disease characterized by a loss of dopamine-producing cells responsible for body movement. There is no cure for PD; treatments available treat only the symptoms while they induce motor complications after ye
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Effects of 5-alpha reductase inhibitors Finasteride and Dutasteride on dopaminergic neurons in a mouse model of Parkinson's disease