Novel functions of the evolutionarily conserved cAMP response element-binding protein (CREB): Identifying and characterizing tissue-specific CREB targets that coordinate whole-organismal decisions related to metabolic status, reproduction, and aging

进化上保守的 cAMP 反应元件结合蛋白 (CREB) 的新功能：识别和表征组织特异性 CREB ​​目标，协调与代谢状态、繁殖和衰老相关的整个生物体决策

• 批准号: 358935
• 负责人: Templeman Nicole
• 金额: $ 10.2万
• 依托单位: Princeton University (New Jersey)
• 依托单位国家: 加拿大
• 项目类别: Fellowship Programs
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-09-01 至 2018-09-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=358935&lang=en
• 关键词: Camp Response Element-Binding Protein (Creb); Lifespan And Healthspan; Metabolism And Energy Balance; Reproductive Aging; Rna Sequencing; Tissue-Specific Transcription Targets

Aging is a progression of deterioration that leads to increased susceptibility to disease and eventually death. Despite the complexities of this deterioration, certain signals acting within a subset of the body's tissues have been found to significantly a

衰老是一个恶化的过程，导致对疾病的易感性增加，最终导致死亡。尽管这种恶化的复杂性，某些信号在身体组织的一个子集内的作用已被发现显着增加了