High-throughput behavioural neurogenetic characterization and precise structure-function analysis of genes and gene variants associated with Autism Spectrum Disorder using Caenorhabditis elegans.

使用秀丽隐杆线虫对与自闭症谱系障碍相关的基因和基因变异进行高通量行为神经遗传学表征和精确结构功能分析。

• 批准号: 367818
• 负责人: McDiarmid Troy A
• 金额: $ 7.65万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-10-01 至 2019-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=367818&lang=en
• 关键词: Autism Spectrum Disorder Genetics; Behaviour Genetics; Behavioural Neuroscience; Caenorhabditis Elegans; Crispr-Cas9; Genetic Model Organisms; Genome Engineering; Habituation; High-Throughput Behavioural Phenotyping; Molecular Genetic Structure-Function A

A primary challenge in investigations of genes associated with Autism Spectrum Disorder (ASD) is the lack of a model system in which to characterize the large number of candidate risk genes in a rapid, cost-effective manner. The time and money constraints

自闭症谱系障碍(ASD)相关基因研究的一个主要挑战是缺乏一个模型系统来快速、经济有效地描述大量候选风险基因。时间和金钱的限制