PCSK9 as a Cholesterolemia-Regulating Gene: Identification and Characterization of Genetic Polymorphisms in Shanghai and Ontario Chinese Populations

PCSK9 作为胆固醇血症调节基因：上海和安大略省中国人群遗传多态性的鉴定和表征

• 批准号: 182658
• 负责人: Mbikay Majambu
• 金额: $ 10.93万
• 依托单位: Ottawa Hospital Research Institute
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-03-01 至 2012-03-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=182658&lang=en
• 关键词: Cardiovascular Disease; Coronary Heart Disease; Genetic Polymorphisms; Genotyping; Hypercholesterolemia; Hypocholesterolemia; Low-Density Lipoprotein Receptor; Pcsk9; Pulse-Chase Analysis; Receptor Binding Assay; Transfection

PCSK9 is a protein released into blood by the liver. Its function is to limit the uptake of blood cholesterol by liver cells. There are many heritably altered forms of this protein caused by mutations in its gene: some rare forms restrict the cholesterol

PCSK9是一种由肝脏释放到血液中的蛋白质。它的功能是限制肝细胞对血液中胆固醇的摄取。由于基因突变，这种蛋白质有许多遗传改变的形式：一些罕见的形式限制了胆固醇