Structural Biology of Tankyrase Activity and Regulation in Cell Signaling
Structural Biology of Tankyrase Activity and Regulation in Cell Signaling
批准号:
354482
负责人:
Pascal John M
金额:
$57.4万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2016
资助国家:
加拿大
项目状态:
已结题
起止时间:
2016-10-01 至 2021-10-01
中文摘要
聚(ADP-核糖)聚合酶(PARPs)产生翻译后修饰聚(ADP-核糖)来调节各种细胞程序,如DNA损伤修复,基因转录,细胞死亡信号传导和代谢。PARP超家族有
英文摘要
Poly(ADP-ribose) polymerases (PARPs) create the posttranslational modification poly(ADP- ribose) to regulate a wide variety of cellular programs, such as DNA damage repair, gene transcription, cell death signaling, and metabolism. The PARP superfamily has
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会议论文
Structural biology and biochemistry of PARP enzyme regulation in the DNA damage response and in cancer therapy
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批准号:419202
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项目类别:Operating Grants
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资助金额:$64.65万
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财政年份:2020
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负责人:Pascal John M
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依托单位:
Structural Biology of DNA Damage-Dependent PARPs
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批准号:322727
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项目类别:Operating Grants
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资助金额:$62.84万
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财政年份:2015
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负责人:Pascal John M
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依托单位:
海外基金