Transcriptional Role of Meis1 in Regulating Endothelial-to-Hematopoietic Transition

Meis1 在调节内皮细胞向造血转化中的转录作用

• 批准号: 365435
• 负责人: Coulombe Patrick
• 金额: $ 7.65万
• 依托单位: B.C. Cancer Research Centre (Vancouver)
• 依托单位国家: 加拿大
• 项目类别: Studentship Programs
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-10-01 至 2019-10-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=365435&lang=en
• 关键词: Developmental Biology; Endothelial-To-Hematopoietic Transition; Gene Regulation; Hematopoiesis; Meis1; Mouse Model; Stem Cell

Hematopoietic stem cell (HSC) transplantation is used to treat a broad range of cancer and blood disorders, mainly leukemia and lymphomas. This therapeutic approach is effective because HSCs are able to produce all the cell types circulating in the blood,

造血干细胞(HSC)移植被用于治疗广泛的癌症和血液疾病，主要是白血病和淋巴瘤。这种治疗方法是有效的，因为HSCs能够产生血液中循环的所有细胞类型，