Comprehensive Analysis of the Impact of Host Immune Response and Antiretroviral Drug Interactions for Precision Patient Treatment and Care

综合分析宿主免疫反应和抗逆转录病毒药物相互作用对精准患者治疗和护理的影响

• 批准号: 366575
• 负责人: Luo Ma
• 金额: $ 7.29万
• 依托单位: University of Manitoba
• 依托单位国家: 加拿大
• 项目类别: Operating Grants
• 财政年份: 2016
• 资助国家: 加拿大
• 起止时间: 2016-11-01 至 2017-11-01
• 项目状态: 已结题
• 来源: https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=366575&lang=en
• 关键词: Anti-Retroviral Drug Treatment; Full Hiv Genome Mutation Analysis; Hiv Disease Progression; Hiv Postive Selected Mutations Before And After Art,; Hiv Replication Fitness; Next Generation Sequencing Technology

HIV mutates rapidly in response to host immunity and antiretroviral therapy (ART). These mutations may have different impact on HIV disease progression and ART outcome. Some may impair viral fitness and slow down disease progression while others accelerat

艾滋病毒在宿主免疫和抗逆转录病毒治疗（ART）的反应中迅速突变。这些突变可能对HIV疾病进展和ART结局产生不同的影响。有些可能会损害病毒适应性，减缓疾病进展，而另一些可能会加速病毒适应性，